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They are characterized by a strong induction of type I interferons (IFNs), potent inflammatory cytokines affecting T cell differentiation and survival.
We detected a strong induction of TGF-ß in CCl4-injured livers, and this induction was significantly reduced by SE in a dose dependent manner (Fig. 2e).
After transplantation, we observed a strong induction of perlecan in the glomerular and peritubular capillary BMs.
A strong induction of COX-2 was noted in particular in large glial cells.
Moreover, we can demonstrate a strong induction of PKCα in podocytes of patients with diabetic nephropathy.
Uterine infection also caused a strong induction of several cysteine cathepsins.
A strong induction of genes associated with these cellular junctions was found after HBO treatment indicating a transition towards an epithelial phenotype (Table 3; Supplementary Table S1).
As expected, such treatment led to a strong induction of both NFAT- and NFκB-dependent luciferase activity in J.Vav1WT T cells.
Animals in group 1 and 3 showed a strong induction of IgA early after vaccination with the exception of animal 2 (Figure 3).
KYSE180-RAGE cells showed a strong induction of NF-κB dependent transcriptional activity, whereas KYSE180-RAGEΔcyto cells did not show significant changes to extracellular S100A14.
Among the cytokines, IL-6 and IL-1 were upregulated to the largest extent, and this was also reflected by a strong induction of the IL-1 receptor.
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