Many important ATP binding interfaces, such as the Q motif and motif VI (Cordin et al., 2004, 2006; Luo et al., 2011; Luo et al., 2012a), are not perturbed by the K270 mutation, and therefore a strong ATP binding cleft can still be formed if it is reinforced by additional interactions with short RNA ligands.
A strong association was found between cleft and non-cleft quadrants in regard to tooth agenesis.
There is also a strong genetic component to oral clefts.
This class of binding proteins, both natural and synthetic, has a strong tendency to bind a preformed cleft using a convex binding interface (paratope).
Correlation analysis between proportions of maize cob particles inthe mixing ratio and compressive strength in cleft of briquettes produced,indicated a strong negative correlation between the two parameters(Pearson's r = -0.770, pvalue = 0.000; N = 60,α = 0.05; one-tailed).
Additionally, a strong significant positive correlation between compressive strength in cleft and compacting pressure of briquettes produced was established (Pearson's r = 0.670, p-value = 0.000; N = 450; 1-tailed, α = 0.05).
Meta-analysis showed a strong association between the presence of the secondary cleft sign and hip/groin pain OR=638.8 (82.9 4925.5).
Facial clefts are common birth defects with a strong genetic component.
It is hypothesized that such a colocalization may produce a strong positive purinergic feedback, with a further amplification due to the concentration of ATP in the synaptic cleft, thus, allowing sensation of just few presented antigens [ 261].
This is a strong argument against using a continuous description of [Ca2+] in small volumes such as the dyadic cleft, but only if the precise position of a certain diffusive ligand is important for the physiological process.
