Sentence examples for a stringent validation from inspiring English sources
PYCARD therefore represented a stringent validation test of the methylation arrays.
The results demonstrate predictive skill using a stringent validation procedure, however, indicating strong model performance even with this relatively limited observation dataset.
We then performed a more stringent validation using in situ hybridization.
A more stringent validation would be to also test whether the SNP is significant in another population (Hayes et al. 2009, Pryce et al. 2010).
A culture of stringent validation has been developed for such approaches (Leist et al. in ALTEX 27(4):309–317, 2010; ALTEX 29(4):373–88, 2012a; Toxicol Res 1 8 22, 2012b), while the quality and usefulness of animal experiments have been little scrutinized.
Protein identification was accomplished by a bioinformatics platform combining two database search engines, Mascot [ 25] and Phenyx [ 26], and an innovative and very stringent validation strategy enforcing a maximum false discovery rate (FDR) of 0.25% on protein groups [ 27].
WHAT THIS STUDY ADDS TO OUR KNOWLEDGE ☑ Compared to the conceptual PK model, the proposed PopPK model is a simplified but valid model that passed stringent validation processes.
Besides their stringent validation, signatures need a functional interpretation and must be placed in a biological context.
In particular, a genome-wide methylation analysis, followed by stringent validation by quantitative methodologies, showed remarkable differences in 84 genes involved in brain metabolism and differentiation [ 79].
Due to the unexpected high rate of suspected off-target hits, we wanted to obtain more stringent validation of our hits and therefore performed a tertiary screen using four additional independent siRNAs that were chemically modified to reduce the chance of off-target effects.
The SCDR participates in international multicentre studies and has a level of ascertainment approaching 100% through efficient entry of incident cases, stringent validation procedures and vigorous data collection.
