This type of method imposes a stringent tree structure on the network which is highly sensitive to the metric used to assess (dis)similarity, and typically requires subjective evaluation to define modules.
The applicability of VNP platform technologies is governed by stringent structure-function relationships.
I think the industry has learned its lesson – stringent structures are in place to make sure it can't happen again: all meat products now have to have a certificate of authenticity, for a start.
The high momentum transfer now achievable for precision coincidence measurements allows a stringent test of nuclear structure theories.
In order to analyze spliceosome structure, a stringent approach was developed to obtain splicing complexes free of cellular contaminants.
Previous in vivo studies in Drosophila find a stringent relationship between tubulin structure and function; small, biochemically similar changes in the major alpha 1 or testis-specific beta 2 tubulin protein render each unable to generate a motile spermtail axoneme.
RNRspBs has a complex three-dimensional structure and thus provides a stringent test of methods for modeling secondary structure.
The ability to engineer novel proteins using the principles of molecular structure and energetics is a stringent test of our basic understanding of how proteins fold and maintain structure.
Because we used a stringent set of criteria on miRNA structure and expression pattern [ 48] for miRNA prediction and identification, it is possible that some real miRNAs were left behind, including some stress-regulated miRNAs.
To identify novel miRNA precursor structures, we applied a stringent filtering strategy [38] to the RNAz output, selecting only RNAz predictions with i) a stem-loop structure exceeding 20 nt, and ii) high predicted thermodynamic stability, as indicated by a z-score of less than −3.5.
In some cases, small RNA with highest expression was not chosen because it did not reside in a hairpin structure that meets the stringent structural requirements for miRNA annotation [ 48, 49].
