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As assessed by either a stringent reduction in pain without increase in the level of analgesic medication or by a 50% reduction in analgesic medication without increase in pain, the palliative response rate was greater for patients receiving chemotherapy (38 vs 21%, P=0.025).
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Nevertheless a post-hoc analysis that applied a more stringent reduction in the SELENA-SLEDAI score revealed significant differences between the belimumab and control groups at several times between week 40 and week 76.
Cogeneration is commonly recognized as one of the most effective solutions to achieve the increasingly stringent reduction in primary energy consumption and greenhouse emissions.
Gov. Arnold Schwarzenegger of California, a Republican, has emphasized in recent speeches that his plan to make insurance mandatory must be accompanied by stringent reductions in health care spending.
Karl Mathiesen (@KarlMathiesen) NRDC said last week that a more stringent reduction plan would create 274,000 jobs.
Utilizing a small number of probes designed as substrate analogs, we were able to expose a limitation in accepted substrate linkages (secondary and tertiary amides) and a flexible catalytic reduction site (C1 vs C3 reduction in diketone thioether substrates), indicating a stringent preference in linkage region with a flexible reduction locale in the active site, respectively.
Critics of the current select agent system have called for more stringent regulation and a reduction in the number of laboratories handling dangerous agents.
The more carbon that is pumped into the atmosphere this year, the more stringent reductions will have to be in future years.
Whilst the Haber Bosch Process can, to some extent, be viewed as a mature technology, the development of more active (or even more poison tolerant) catalysts which would allow a reduction in the stringent conditions of operation is of significant interest.
The most stringent search conducted, Search D, yielded a marked reduction in sensitivity for confirmed loci (Figure 2), especially in V. cholerae and P. aeruginosa, where the proportion of confirmed transcripts identified dropped from 60% to 10% and from 79% to 14%, respectively.
Traffic congestion has become a stringent issue in urban areas.
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