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We selected a stringent level of significance because we were doing multiple tests of association.
On the other hand, successful preclinical use of a biological tool requires a stringent level of justification for the proposed use of the tool.
The search criteria were set at a stringent level (e-value > E-50) in order to select sequences with a relatively high sequence alignment length and homology to the microarray query sequences.
In addition, many metabolites found to be associated with diabetes at a stringent level of significance in one biofluid were also associated at a nominal level of significance in the other biofluid(s).
These can be based on detecting modest differences in individual genes (gene selection phase) with good power (i.e. 80 90%) at a stringent level of significance (i.e. 0.1 1%) that will help control for multiple comparisons.
The cleaned data were clustered with Vmatch at a stringent level, where the default parameter setting was used, as applied in a number of SNP mining programs [ 30, 45].
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G.M. says it intends to seek certification as a Partial Zero Emissions Vehicle, a more stringent level that carries a longer warranty and allows no evaporative emissions, which will be needed in some states for access to special high-occupancy-vehicle lanes on freeways.
For replication purposes this leads to a less stringent level of statistical significance, and potentially to a higher likelihood of finding susceptibility variants.
When pruning the entire data set (containing ~6M SNPs) at a very stringent level of SNP pruning (r 0.001; resulting in a set of nearly independent SNPs), DE estimates were 13, 11, and 15% for GGT, ALT, and AST, respectively.
Along with this growing understanding of the importance of sunscreen protection for skin cancers, the FDA released new labeling guidelines on June 14 , 2011 to ensure a more stringent level of sunscreen labeling and product quality.
In large-scale studies, when thousands to millions of loci are measured, the threshold to declare any locus significant is typically based on a more stringent level of significance (e.g. Bonferroni correction or similar) in order to minimize the possibility of false positives, therefore we have displayed the power at two such thresholds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com