Mice immunized with decreasing amounts of PapMV-sM2e and challenged with a more stringent dose of influenza virus displayed dose-dependent levels of protection.
Due to stringent dose modification guidelines, only a small proportion of patients experience serious functional impairment.
Such a finding could revolutionise the development of personalised RT (e.g., utilising very stringent dose constraints for surrounding normal tissue or avoidance of RT if feasible for patients predicted to be at higher risk for developing radiotoxicity).
The similar extubation times in the remifentanil and fentanyl groups in the present study probably reflect the stringent dosing guidelines and close monitoring of patients to maintain a target sedation level, which prevented any significant accumulation of fentanyl.
Oral bisphosphonate dosing requires stringent dosing guidelines to maximize bioavailability and minimize UGI irritation.
The stringent, dose-responsive, and conditional gene regulatory system described herein will provide synthetic biologists with a new means for wiring and rewiring similar types of circuits with the added potential of multiplexing.
Overall, the main reasons patients cite for not continuing to take their osteoporosis medication are the stringent dosing schedule, adverse events, not feeling that treatment is working, or not believing that they have a disease that needs treating (see Figure 2) (IOF 2005).
We predict that, had we used higher doses of antibody, or a less stringent challenge dose, we would have observed a significant correlation between reduction in viral load and survival.
This low NP dose was selected as a stringent test based on the high and specific potency of targeted LIF-NP for inducing OPC differentiation in vitro.
Furthermore, baseline glycemic control of patients was poor despite the fact that the great majority were using basal-bolus therapy; hence, the cohort can be regarded as a stringent one in which to evaluate once-daily detemir dosing.
