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Despite this general picture, the exact topography of the dopaminergic and serotonergic nerve fibers, their varicosities, and/or their terminals with respect to the various structures and cell types engaged in saliva production and modification is still insufficient for a stringent correlation of innervation and gland physiology.
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Unfortunately, from the many mechanisms, no single one shows a stringent correlation with the inhibition of bone resorption in vivo when different bisphosphonates of various potencies are investigated.
We interrogated urine proteomic profiles generated by surface-enhanced laser desorption/ionization-time of flight/mass spectrometry with the aim of isolating a set of biomarkers able to reliably identify biopsy-proven diabetic nephropathy and to establish a stringent correlation with the different patterns of renal injury.
The choice of GAPDH as a reference gene was based on GAPDH having a stringent correlation in the lung cells and the least variation of the seven common reference genes [ 21].
We chose such a stringent correlation threshold considering the relatively small sample size in the analysis so that gene pairs in the coexpression network are statistically significant (P = 0.0005 using Fisher's Z transformation), meaning the probability of randomly obtaining a correlation coefficient of ≥ 0.90 in this seed transcriptome dataset is small.
There was no stringent correlation of actual PCDD/PCDF concentrations with the occurrence of infections or with one of the immune parameters.
An unsupervised hierarchical clustering analysis can then divide patients into groups based on their B-cell profiles, and stringent correlations of B-cell fingerprints with clinical, immunological and other emergent features can be identified.
The presence of SARD1 and absence of CBP60g in the SID2 cluster with the more stringent correlation threshold of experiment #1 imply that the combined dataset may be weighted towards later timepoints in infection, understandably since these have higher probability of uncovering large scale differential expression in relatively costly gene expression profiling studies.
No stringent correlation between the amount of processing of caspase-9 and effector caspases was seen.
The stringent correlation between the frequencies of IL-2 and IFN-γ producing memory Th cells after graded stimulation with ionomycin or graded inhibition of stimulation by CsA confirms this view (Supplementary Fig. S5).
More stringent correlation thresholds reduce the number of genes correlated to at least one other gene at or above that threshold.
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