A more stringent application of the sufficient interest test would be in line with the green-light approach that the courts adopt in administrative law.
A less stringent application of the same notion asks whether X has been tolerated in a homologous protein that is not a direct ancestor of the current population of interest, but is related as a "distant cousin".
The number of genes highly modulated in control berries (567) was small in comparison with previous studies [ 22, 40] but this reflects our stringent application of the requirement for a fold change > 5.
While at Oxford, he wrote his satiric Historic Doubts Relative to Napoleon Bonaparte (1819), in which he attacked the stringent application of logic to the Bible by showing that the same methods used to cast doubt on the miracles would also leave the existence of Napoleon open to question.
One potential reason was our stringent application of the DSM-IV criteria, which might have led to an underestimate of the true rate of ADHD in the SUD population for several reasons.
Although the combination of intense blood pressure and blood glucose lowering therapy has been shown to reduce (microvascular) complications [ 129– 131], stringent application of multiple blood glucose lowering drugs does not necessarily result in a further reduction of macrovascular events [ 130, 132– 132].
It could be argued, for instance, that randomised trials with low mortality rates reflect publication bias, or perhaps the stringent application of guidelines in inclusion criteria limits exposure of at-risk patients and that, consequently, external validity or applicability of these data may be limited.
GPs and specialists highlighted delays in patient help-seeking, difficulties applying the colorectal cancer referral criteria due to their low predictive value, and concerns about the stringent application of targets because of potential impact on individual care and associated penalties for breaching.
In addition to delays in patient help-seeking, clinicians highlighted difficulties applying the TWW referral criteria for CRC, and concerns over the stringent application of waiting time targets (and associated penalties for breaching targets) which were perceived as potentially compromising patient-centred care.
