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When EGFR mutations were first reported, the most exciting finding was that lung cancer harbouring this genetic alteration showed a striking response to EGFR-TKIs (Lynch et al, 2004; Paez et al, 2004; Pao et al, 2004).
In fact, it is somewhat surprising that B cell depletion elicited a striking response in patients with PM, which is characterized as a T cell-mediated autoimmune disorder [ 8].
Importantly, detailed dissection of the molecular characteristics of the biological samples of patients experiencing either a striking response to any given anticancer treatment or a particularly aggressive course of the disease will potentiate our ability to identify biomarkers of sensitivity or resistance to the applied therapeutics.
Apparent elastic fragments within giant cells, immunoglobulin deposits adjacent to the internal elastic lamina, proliferative responses of lymphocytes to arterial tissue in vitro, and a striking response of mononuclear cells to elastin peptides all lend support to this idea, although none of these findings have been replicated convincingly [ 5].
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In tasks with high perceptual load, responses to visually striking images, such as high-contrast stimuli, are significantly reduced.
At Wimbledon in 2004 the teenager gave another striking response to a question posed after her semi-final.
Closer examination of the expression of genes from terpenoid metabolism demonstrated a striking biphasic response.
A striking inflammatory response was found in paralytic rabies in the brainstem.
We observed a striking sympathoadrenal response in our patient despite therapy with irbesartan HCT, a selective AT1R inhibitor.
The expression pattern of the other three genes showed a striking biphasic response, with nearly identical magnitudes of induction in irradiated and bystander cells at all times.
PBP/MED1ΔLiv mice, killed at 1, 4 and 12 weeks, revealed a striking proliferative response of few residual PBP/MED1-positive hepatocytes that escaped Cre-mediated deletion of PBP/MED1 gene.
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