Birdsong is a complex vocal behaviour often considered to show striking developmental and structural similarities with human speech [1].
Similar to mice deleted with all p63 isoforms, ΔNp63-null mice have striking developmental defects including truncated forelimbs, the absence of hind limbs, and a lack of stratified epidermis [ 27].
However, unlike mutants in other RNAi components like Dicer-2 or Ago-2, we report here that r2d21 mutants have striking developmental defects.
And when the team examined the brain tissue of the homozygous knockout mice, it found striking developmental abnormalities in the cerebellum, especially in the Purkinje cells, which are involved in fine motor control.
Deviations of only one degree from optimum induced striking developmental reductions in sensory mode-specific zones of the calyx, the dendritic input of the MBs [15], [16].
One goal of our comprehensive microarray analyses of gene expression was to identify candidate genes involved in the striking developmental changes (cell pairing, meiosis, fertilization, RNAi-mediated scanning of MIC-specific sequences, chromosome fragmentation, telomere addition, rDNA amplification and the DNA splicing events of IES elimination) that occur during conjugation.
Kidins220−/− embryos display striking developmental heart defects.
The most striking developmental defect is reduction in the size of the brain and eyes when observed at 1 dpf.
The indirect-developing Ptychoderidae is of particular interest because their tornaria larvae share striking developmental and morphological similarities with echinoderm larvae [ 40- 42].
Although many of the most striking developmental changes occur during early development, reproductive maturation represents another critical window in primate life history.
