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We find that MS and PS genes differ particularly in the number of tissues and cell types where they are expressed.We find a striking deficit of PS genes on the sex chromosomes, particularly on the Y chromosome where it is shown not to be due to the observed lower breadth of expression of genes on that chromosome.
We found that males with ablated SF1+ neurons showed a striking deficit in predator avoidance behavior compared to controls, as demonstrated by a significant increase in the time spent in the zone closest to the rat.
The lack of cross-nation comparisons is a striking deficit in the study of self-injury because it precludes drawing conclusions that could inform international policies and efforts to prevent these behaviours among adolescents.
Given that females deficient for Vmn2r116 show a striking deficit in lordosis [ 1] and that ESP1 detection is severely reduced in VSNs lacking Gαo [ 41], the display of lordosis should also be affected in cGαo-/ females.
Box plots reveal a striking deficit of large neurons in subjects with dup(15) autism, with only a few neurons in the top range of control or idiopathic autism cases.
Conversely, expression of UAS-EGFP-MenaΔ GAB or UAS-EGFP-MenaΔ CC transgenes, which contain deletions in the G-actin binding or coiled-coil motifs, respectively, revealed a striking deficit in the recruitment of EGFP-Mena to the peribouton area (Fig. 3E-E″,G-G″).
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Consistent with our observation of the striking deficit of pathogenic variants in AAs, Dorschner et al. [ 9] reported that only 3 out of 18 pathogenic or likely pathogenic variants were present in individuals of African descent.
The striking deficit in inhibitory synaptic function observed in Lhx6 null mutants could be secondary to the migratory defect associated with deletion of Lhx6, as failure of interneuron precursors to reach their final destination on time could prevent them from establishing functional connections with their post-synaptic targets.
John made a detailed examination of James's cognitive profile -- a mix of "striking strengths and equally striking deficits". What followed was an isolating time for James, at a little table for up to eight hours a day, doing work most children would find tedious in the extreme.
9– 14 Within the neurodegenerative disease spectrum, the behavioral variant of frontotemporal dementia (bvFTD) produces striking deficits of music emotion processing as part of a wider syndrome of selective brain atrophy (chiefly affecting the frontal and temporal lobes) with impaired emotional understanding and responsiveness and profound disruption of interpersonal conduct.
However, these MAP2 knockout and mutant mice also have striking deficits in dendritic elongation and dendritic architecture [69], [70] that could contribute to the mislocalization of PKA and perhaps the mislocalization of other scaffolding proteins such as AKAP5.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com