Sentence examples for a strict dose from inspiring English sources
Also, interactions between levels of ARA and DHA supplied in our study add some complexity to the interpretation since the three treatments do not represent a strict dose response to DHA.
Thus, as observed in the mouse TB model, there was a strict dose dependency regarding the antigen Ag85B-TB10.4, buthehe optimal dose of Ag85B-TB10.4 also induced significant protection in the guinea pig TB model.
The profoundly protein-bound drugs nilotinib and dasatinib have been shown to be active even at subnanomolar concentrations [ 3]; in vitro data suggest considerably higher activity compared to imatinib and there might not be a strict dose-response relationship.
Symptom description in self-report questionnaires may be a limitation in a strict dose-response discussion; however, frequency as well as intensity and duration of pain and dysfunction are important variables in health care seeking behaviour [ 48, 49].
This pharmacodynamic profile leads to a strict dosing schedule, ie, IDeg is injected at the same time each day to ensure optimal biological action and consistent glycemic control.
Consequently, anticoagulants require strict dose titration and monitoring, and there remains a pressing need for safe, yet effective agents to improve the treatment of thrombosis.
Similarly, strict dose reductions of ACEI and ARB by an automated decision support system will only be appropriate if relevant patient characteristics such as the indication (hypertension vs. renal protection in CKD) are available and considered.
The Netherlands Commission on Radiation Dosimetry (NCRD) recently published diagnostic reference levels (DRL), including potentially achievable levels after strict dose optimisation [14].
The mechanism of this strict dose dependency of the effect of PTX is unknown.
Strict dose modifications for toxicities were enforced, without attempts at dose re-escalation.
However, it is possible that rescue of this defect by K04G2.2 requires strict dose dependency.
