Furthermore, microRNAs have also been described as positive regulators at transcriptional level of mRNA expression [ 9– 11], with a strict dependency on the cellular context [ 12].
However, the approach (Fig. 1) does not have a strict dependency on one database type.
We showed that, following lentivirus vector-mediated gene transfer, the reporter units display low basal activity and a strict dependency on the FLP recombinase for their activation.
An increase in concentration usually leads to suspension coagulation, but for nanotube dispersions, a strict dependency is not observed.
These beneficial effects were not observed with a reporter virus (eGFP) or a catalytically inactive TERT (TERT-DN) demonstrating the strict dependency of an active telomerase complex.
The strict dependency of laser process simulation results on the physical parameters describing the target material is, in fact, a well known matter, especially considering that the values of these parameters change during the process dependently on temperature and time.
This result again stresses the strict dependency of malignant cells on early molecular events acquired during tumorigenesis.
With respect to NSP1, it might surprise that the strict dependency of Myc-LCO related gene expression on this GRAS TF contrasts with the comparably mild AM infection phenotype of nsp1-1 mutants [ 35, 36].
Thus, as observed in the mouse TB model, there was a strict dose dependency regarding the antigen Ag85B-TB10.4, buthehe optimal dose of Ag85B-TB10.4 also induced significant protection in the guinea pig TB model.
