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On the other side the consequent rise in blood glucose levels [ 4] is expected to be more marked in diabetic than in non-diabetic mothers thus requiring a strict adjustment of the insulin therapy.
Last but not least, we cannot exclude a chance that variations in the administrated drugs and diets may affect our findings on GCK methylation, although our results have been employed with a strict adjustment by multiple factors including hypertension, smoking habit, and diabetes.
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In March 2000, the IMF agreed to a three-year $7.2 billion stand-by arrangement with Argentina, conditioned on a strict fiscal adjustment and the assumption of 3.5% GDP growth in 2000 (actual growth was 0.5%).
We believe that a strict Bonferroni adjustment for multiple testing would have been overly conservative.
Neighboring SNPs on a chromosome tend to be inherited together in blocks and are not independent [ 3], making a strict Bonferroni adjustment overly conservative.
To avoid the strict adjustment required in multiple testing, we developed a genome-wide Bayesian association method to test for association of a single SNP with a case-control phenotype.
To avoid the strict adjustment required for multiple testing, Bayesian approaches compare the probability of an association to the probability of no association.
Therefore, although the results of these studies did not prove causality, they suggested that high ESA dose rather than the Hb level was associated with adverse outcome, reinforcing the actual recommendations about the strict adjustment of ESA dosage and the close monitorization of Hb levels.
A strict physiotherapy protocol prohibited an individual adjustment of treatment, and may have influenced results.
This may be explained by a strict and prospective adherence to the protocol for heparin adjustment, which was not the case in our previous retrospective study.
If a strict Bonferroni correction were taken, none of them would survive adjustment for multiple comparisons after multiplying the observed P values by seven or 46.
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