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The result is faster and louder than a straightforward simulation.
We will show here with a straightforward simulation study that the "information from all measured relatives" is a prime source of false-positive results in GWAS.
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The current simulation model is simplified in order to maintain a straightforward model structure and avoid introducing unnecessary artefacts of the simulation process into the evaluation datasets, which may bias the evaluation findings.
The study's aim is to validate the prediction quality of two existing analytical models and a novel straightforward simulation technique, which utilizes measured spring-in distortions of representative monolithic samples as input.
We first compared all methods using a straightforward power simulation where a single gene had a single sample outlier with a true effect size ranging from three to five units, and where data were either generated from a re-centered normal or t-distribution to capture the range of sample-sample variability to which actual samples might belong.
Implementation is performed in EDStar, an open-source development environment that enables straightforward simulation of reactors with any geometry (directly provided by their CAD-file), with the very same Monte Carlo algorithm.
The methodology can efficiently design for very small transponder-related blocking probability (e.g., <10−4) by using simple, straightforward simulation and analysis techniques.
The combination of SIMPSON and SIMMOL allows straightforward simulation of the response of advanced solid-state NMR experiments on typical nuclear spin interactions present in polypeptides.
Because of the long-range dependent nature of the PPBP, straightforward simulations are unreliable.
The computing time needed to run the hydrologic model this many times renders the straightforward simulations operationally infeasible.
The results may also be different from the straightforward simulations, as the simulations did not take into account the use of multiple refocusing pulses with concomitant magnetisation transfer effects, and the variation in T2 values across field strengths.
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CEO of Professional Science Editing for Scientists @ prosciediting.com