Sentence examples for a straightforward hypothesis from inspiring English sources

Results from this study and the previous study reporting miR-141 elevation in metastatic prostate cancer [12] link miR-141 to metastasis, we thus tested a straightforward hypothesis that the elevated plasma miR-141 reflected the elevated miR-141 level in tissue in Stage IV colon cancer patients.

However, the roles of laminin-binding integrins in metastasis are more complex than such a straightforward hypothesis would suggest, and, depending on the context, the laminin-binding integrins may in fact possess antimetastatic functions.

It is a straightforward hypothesis that digenic or perhaps even trigenic combinations of non-synonymous variants may occur in either of the NPHS2, ACTN4, TRPC6, CD2AP, or even PLCE1 genes in FSGS patients (especially those with sporadic disease).

A straightforward hypothesis emerged that plasma gelsolin scavenges actin leaked into the circulation or interstitial space from injured tissue in order to abort subsequent damage instigated by extracellular actin filaments [ 2].

This therapy stemmed from a straightforward hypothesis to explain the disease pathogenesis, namely that progressive enlargement of glycogen-filled lysosomes would lead to lysosomal rupture and to release of glycogen and toxic substances into the cytosol., The assumption was that early treatment, initiated before lysosomal integrity was compromised, would reverse this pathogenic cascade.

The overall methodology is a straightforward hypothesis-generation, testing, and refinement cycle.

Eugene Koonin, National Center for Biotechnology Information, National Library of Medicine, National Institute of Health, Bethesda, MD USA This paper presents a simple and straightforward hypothesis regarding the function of the bacterial PrfH proteins, a homolog of class 1 release factors.

In summary, the nature of the relationship between eukaryotes and archaea deserves further, careful investigation but at present I cannot see how we can reject the straightforward hypothesis of an archaeal host for the mitochondrial endosymbiont.

The pharmacologically guided dose escalation (PGDE) design is based on a straightforward PK PD hypothesis.

Detection power is examined under a straightforward alternative hypothesis and found to be generally acceptable.

The most straightforward hypothesis to explain all current observations is that a conformational activation of α-catenin occurs in mammalian cells that allows simultaneous binding to the Cadherin complex and actomyosin, which cannot be recapitulated in lysates with mammalian expressed α-catenin proteins.