Sentence examples for a stepwise transformation from inspiring English sources

We thus tested the effect of GATA3 in a stepwise transformation model, in which hMEC are transformed by sequential introduction of genes encoding the telomerase catalytic subunit hTert, SV40 large-T antigen (LT) and the oncoprotein H-Ras [ 31].

In the last decade, a stepwise transformation of paper-based patient records into electronic records has been accomplished in most clinics.

A theory of stepwise transformation of low-grade dysplastic nodules into high-grade dysplastic nodules and finally into HCC has been proposed and some supporting evidence is available [ 37– 37].

Previous dogma suggested a genetic basis for breast cancer metastasis as an extension of the stepwise transformation model, whereby the accumulation of genetic mutations confers selective survival and proliferative advantages to reach a malignant state of growth.

Some of the initial reconstructions of the pulmonary condition in nonavian dinosaurs were characterized as the "stepwise transformation of a crocodilian-like lung into an avian airsac system" [74: 132].

In the stepwise transformation of N. gonorrhoeae from a penicillin-susceptible strain to a strain exhibiting high-level resistance, acquisition of a mutated allele of PBP2 is the first and prerequisite step.

Upon stepwise transformation, the copy numbers of crtYB was continuously increased leading to an almost saturated level of phytoene synthase as indicated by total carotenoid content.

Indeed, we have recapitulated these effects with the stepwise transformation system (Fig. S7).

Examining productivity patterns of classic, recently domesticated and newly adopted fruit trees provides clues to the stepwise transformation of the wild forest tree into the modern plantation tree.

In this model, type I tumours consist of low-grade neoplasms that undergo stepwise transformation from benign and borderline tumours into malignant carcinomas.

While enhanced neuromuscular activity or chronic low-frequency electrostimulation causes a stepwise fast-to-slow transformation process in skeletal muscle, disuse-related muscular atrophy or complete denervation is typically associated with slow-to-fast transitions [ 10– 10].