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According to Darwinian theory, complexity derived by a stepwise process of elaboration and optimization under natural selection [ 25, 26].
It is becoming clear that carcinogenesis is a stepwise process of accumulation of both genetic and epigenetic abnormalities that can lead to cellular dysfunction.
This may suggest a stepwise process of additive mutations (as described for FQ-R) that could generate higher levels of resistance to RMP [ 14- 16].
The progression from normal cell, subject to stringent growth controls, to an unregulated tumor cell is a stepwise process of accumulating mutations and rearrangements in the genome [ 1], which may disrupt, inhibit or deregulate genes, or create novel fusion genes.
23 The basic underlying idea of Grounded Theory is to develop a specific, short-range or middle-range 'theory' in a stepwise process of analysis, that is, 'grounded' in the data.
The association of GKPID with Pins in the spindle orientation complex therefore evolved through a stepwise process of molecular exploitation (Bridgham, 2006) – a form of exaptation in which a newly evolved molecule recruits as a binding partner a more ancient molecule, which previously had different functions and a fortuitous but unrealized affinity for its new partner.
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The PW intervention consists of a stepwise process to identify and solve barriers for RTW, based on consensus between the sick-listed employee and his/her supervisor about a plan to facilitate RTW.
This program, based on participatory ergonomics (PE)[ 8, 9] consists of a stepwise process to identify and solve obstacles for RTW by the sick-listed employee and his/her supervisor, resulting in a consensus based implementation plan to facilitate RTW.
The newly developed RTW program consists of a stepwise process to identify and solve obstacles for RTW by the sick-listed temporary agency worker or sick-listed unemployed worker and his/her labour expert from the SSA, resulting in a consensus-based implementation plan to facilitate (therapeutic) RTW.
This translation was performed by linguistic validation, which is not a literal translation but a stepwise process to produce a conceptually equivalent of the original questionnaire[ 23].
Our previous single-molecule fluorescence studies led to a model according to which branch migration is a stepwise process consisting of consecutive migration and folding steps.
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