Sentence examples for a step upstream from inspiring English sources

These results suggest that palmitic acid acts at a step upstream of p53 but downstream of foci formation.

These results suggest that endogenous optineurin inhibits TNFα-induced NF-κB activation and this inhibition occurs at a step upstream of IκB degradation.

Hence, 4-BPB appears to block invasion at a step upstream of the effect of cytochalasin-D, i.e., before rhoptry protein release.

Thus, clofazimine appeared to act at a step upstream of calcineurin activation in vivo, raising the possibility that it affected either the release of intracellular calcium or calcium influx through the plasma membrane calcium channels.

We found that the presence of SFAs compromised cell response to DNA damage in primary cells but not in immortalized or transformed cells, at a step upstream of p53 and Chk1, likely Atr.

This suggests that SUMO knock down does not impair the processes downstream of Ras1 activation, so SUMO pathway affects a step upstream of Ras1 or at the level of Ras1 to activate the pathway.

In contrast to the case for PRPP, the intracellular levels and C incorporation into the pyrimidine biosynthetic intermediates dihydroorotate and orotate decreased drastically after feruloyl amide and coumaroyl amide treatment (Fig. 3), which suggested inhibition of a biosynthetic step upstream of dihydroorotate.

These results are consistent with celastrol inhibiting an intoxication step upstream of Nalp1b inflammasome activation.

Beneath the mezzanine, a grey heron breaks the spell of its statuesque pose to step a pace upstream among the handful of mallards that always dally here.

A first issue to be considered on an AG AACA HRE sequence is that the placing of the AA central step upstream to a CA step facilitates a local kink, promoting a "depression" of the major groove surface at the region where the recognition helix allocates [ 32].

This moves the question of how paclitaxel kills breast cancer cells a step further upstream from the mitochondrion.