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Since the data was not large enough to make a statistically significant comparison, this data was not used the for our analysis.
The bias was even more pronounced for integrations occurring on the X chromosome, although their number was too small to allow a statistically significant comparison: 7 out of 8 (87.5%) X chromosome-specific, intragenic integrations were in reverse orientation in the post-infusion dataset vs. 28 out of 64 (44%) observed in pre-infusion cells.
Sequencing a number of clones from the test and the reference population of phage-Ab could reveal clones which are differentially represented in the two pools, but clearly, a statistically significant comparison of the two populations would require a very large number of sequences.
A second, and more influential, factor affecting the number of cases needed to reach a statistically significant comparison was treatment complexity.
It is important to note that both ARDS animal models were different in many aspects and do not allow for a statistically significant comparison.
In our study, we did not analyze clone-specific risk factors because we did not believe that we truly had an epidemic clone and because the number of patients affected by each clone was too small to allow a statistically significant comparison.
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In 40 studies, all statistically significant comparisons (P<0.05) favoured not-for-profit facilities; in three studies, all statistically significant comparisons favoured for-profit facilities, and the remaining studies had less consistent findings.
The grouped analysis revealed one statistically significant comparison between barefoot trials for the root mean square greater than 60 Hz variable.
The study was designed as a proof-of-concept and was not powered for statistically significant comparisons between groups.
Statistically significant comparisons, p≤0.05, are denoted with an asterisk.
The study was designed to be a proof-of-concept study and was not powered for statistically significant comparisons.
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