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The phrase "a state of despair" is correct and usable in written English.
It can be used to describe a condition or situation where someone is experiencing deep sadness or hopelessness.
Example: "After losing his job and facing personal challenges, he found himself in a state of despair."
Alternatives: "a condition of hopelessness" or "a feeling of despondency."
Exact(48)
"Our house was sort of in a state of despair.
Butterworth looked on in a state of despair.
For several months she has withdrawn from the world in a state of despair.
The loss of their jungle has left them in a state of despair.
It's as if they're inhabiting a state of despair – and so are you, the viewer.
"I fought very hard to not end up in a state of despair.
Similar(12)
Then he withdrew into a state of petulant despair.
His wife has died and left him in a state of nihilistic despair.
But for an album written in a state of crippling despair it was often astonishingly pretty.
Many of those conservatives are now in a state of stunned despair.
"The alternative to a ceasefire is 1.5million Palestinians continuing to live in a state of utter despair.
More suggestions(17)
a state of nature
a landscape of despair
a litany of despair
a state of unrest
a moment of despair
a state of flux
a state of urgency
a state of war
a state of confusion
a state of purpose
a state of euphoria
a state of anarchy
a trough of despair
a religion of despair
a state of siege
a state of upheaval
a counsel of despair
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com