The authors contend that such an approach is classically used in pharmacogenetic studies where the disparate response to a standardised dose of drug provides a dynamic phenotype (high vs low metabolisers or responders vs nonresponders) from which to identify relevant genes [75].
The antibiotic regimen was determined by the primary treating ICU physician on the basis of a standardised dose regimen, the clinical follow up and response.
Groups were treated according to a standardised dose-escalation scheme, depending on the worst toxicity experienced by patients enrolled at the prior dose level, and the clinical significance of that toxicity.
In contrast to Hospital D, Hospital A had developed an 'opt-out' policy where all patients (irrespective of admittance speciality) were given a standardised dose of pharmaceutical prophylaxis unless it has been contra-indicated.
A visual predictive check (VPC), 36 a modelling tool that estimates the concentration prediction intervals and graphically superimposes these intervals on observed concentrations after a standardised dose, was used to evaluate how well the model predicted the distribution of observed dexmedetomidine concentrations.
Infiltrates were most apparent 3 and 10 days after a single standardised dose of UVB.
We previously showed that induction of SBCs in the skin of patients with SLE does not differ from that in healthy controls after a single standardised dose of UVB [ 16].
In the present study, we demonstrated that the rate of clearance of apoptotic cells after a single standardised dose of UVB is not decreased in the skin of patients with SLE.
GPs prescribed ACE-I to 45% of their patients and had previously initiated such treatment in an additional 3.5%, in an average standardised dose of 13.5 mg.
The GPs prescribed an ACE-I to an average of 44.9% (SD 15.9) of their CHF patients in an average standardised dose of 13.5 mg (SD 6.6).
