In the case of children with disabilities, this includes ensuring a safe and stable progression through childhood and into adulthood.
Five patients showed a stable disease/tumour progression on CT scans/MRI as well as a persisting elevation/increase of tumour markers.
The triangle of increasing radiological damage, worsening function with longer disease duration has been described by many others, varying from stable progression rate [ 17] to a steeper worsening, but earlier plateau [ 18].
Successful programs include key program design considerations such as ensuring a stable baseline before progression, treating the right impairments and activity limitations, understanding contextual factors, considering the principles of specificity and optimal loading, and applying dosing principles.
Patients on TRA could have a treatment response [have a stable disease (SD ], disease progression (PD) or they could die.
Two patients experienced recurrence; one patient experienced liver metastasis but was still alive and in a stable condition without further tumor progression 12 months after surgery.
One patient had a partial response, while another patient had a stable disease; the time to progression of these patients was 12 and 7 months, respectively (Young et al, 2006).
Superimposed on this gradual progression towards a stable geography are ongoing disturbance regimes ranging from low-frequency, high-magnitude events (megafloods, volcanic eruptions) to high-frequency, low-magnitude events (small landslides, annual floods).
Several investigators have assessed the relationship between HRQoL and tumour response in patients with breast, colorectal and renal cell cancer, 7 10 and suggest that patients who remain on treatment and who experience delayed progression have a stable HRQoL or experience a less rapid decline in HRQoL than patients whose tumours are progressing.
