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This ability of the antibody to select a stable conformation is conform to recent molecular modeling calculations which indicate that a proportion of short antigenic peptides could adopt the desired stable conformations and generate antibodies that in turn will recognize this conformation within the native proteins [64].
To obtain their 3-D atomic coordinates, we used the CORINA program [38] with which a stable conformation of each molecule was generated on the basis of the conformational parameters derived from the X-ray crystal structures of small molecules.
In contrast, dimer has a stable conformation during simulation.
This created a stable conformation of the molecule 8 in the hydrophobic binding site of the COX-2 protein.
It was found that the P′0 molecule exists in a stable conformation with planar phthalocyanine core.
Interestingly, miRNA binding confers remarkable stability on hAgo2, locking this otherwise flexible enzyme into a stable conformation.
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This is the only instance of a significant stable conformation with a syn OH/CH3 relationship.
However, in the case of ADP 355, from 80 ns to 250 ns, the RMSD remained around 0.6 nm, indicting that the peptidomimetic folded into a more stable conformation characterized by a hairpin incorporating almost the entire peptide.
Here, we propose a more stable conformation, referred to as a dynamic inner-layer and outer-tail (DILOT) conformation, to describe the conformational evolution of DNA on AuNP.
In contrast, protonation at the p-NH2 results in a more stable conformation which fragments through a mechanism similar to that of 4,4′-MDA.
Many proteins have regions that remain 'unstructured' unless bound to a substrate: they do not adopt a unique stable conformation in isolation.
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