The traditional house represents a spontaneous model that refers to a humble experience of local skills and the limitation of the available local construction materials.
We characterized the features and mechanisms of chronic gastritis in SAMP1/YitFc (SAMP) mice, a spontaneous model of CD-like ileitis, along with possible therapeutic approaches.
Importantly, in both TNFα triggered RGC death and a spontaneous model of glaucoma, gene-targeted mice that express only full-length FasL exhibit accelerated RGC death.
We have compared the ability of these mice to develop RGC degeneration following intraocular TNFα treatment and in a spontaneous model of glaucoma.
Because islet inflammation may originate from endothelial cells, we assessed the expression of selected genes involved in endothelial cell activation in islets from a spontaneous model of type 2 diabetes, the Goto-Kakizaki (GK) rat.
Considering the widespread hypothesis that SLE is related to deficient clearance of apoptotic debris, and in particular to the removal of chromatin-associated antigens, impaired production of a key secreted renal nuclease in a spontaneous model of the disease is a striking observation.
