The phrase "a split alignment" is correct and usable in written English.
It can be used in contexts related to formatting, design, or alignment in various fields such as graphic design, programming, or document editing.
Example: "The document requires a split alignment to ensure that the text is evenly distributed across the page."
Alternatives: "divided alignment" or "segmented alignment".
When preliminary urban routes were laid out in 1955, a split alignment was chosen to serve both cities equally.
We measured the percentage of queries with a split alignment that verified the correct SV breakpoint (within 5 bases) and the total number of verified breakpoints (Fig. 3A).
The authors detected mis-assemblies by finding contigs that have a split alignment to the optical consensus map, then selected the assemblies with highest contiguity (i.e., with the most resolved repeats), but which did not exhibit any mis-assemblies with respect to the optical map.
Our approach starts with assembly-versus-assembly alignment, for which we use the LAST aligner [ 16] with the application of a split-alignment algorithm (Martin Frith, personal communication).
Also, although the pipeline that was built around SPANNER was able to utilize the SR signal, its split alignment algorithm is only compatible with reads collected using the now defunct 454 sequencing technology.
Even (split) alignment based approaches may fail to provide accurate breakpoints, as accurate gap placement in alignments has remained an algorithmic challenge in bioinformatics (see e.g. [ 26] for a description of effects such as gap annihilation, gap wander and so on).
This allowed Pindel to successful perform a split-read alignment with the reads containing the deletion and so identify this variant.
A split-read alignment by dynamic programming is prohibitively expensive for the full set of putative split-reads and hence, DELLY uses a fast k-mer-based filtering technique to identify candidate split-reads.
We have implemented a split-read alignment analysis procedure that accurately predicts mutational events leading to structural variation in clonal samples of haploid microbial genomes as part of the breseq computational pipeline [ 21].
This approach allows us to report multiple overlap alignments (including split alignments) for an experimental map while using the q-value analysis, as before, to report all alignments with q≤0.01.
MSAs that did not meet these criteria were manually inspected to evaluate further manual editing (split alignments).
