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The phrase "a speculation that the" is correct and usable in written English.
It can be used when discussing a theory or hypothesis regarding a particular subject or event.
Example: "There is a speculation that the recent changes in climate patterns may be linked to human activity."
Alternatives: "a theory that the" or "a hypothesis that the".
Exact(12)
The popularity of the theme in the colonies owed something to a speculation that the New World's indigenous natives were descendants of the ten Lost Tribes, which had vanished from history.
This should lead to a speculation that the variation of entry size is further related to some other factors like deformation of low backfilling side or displacement of roof/floor.
There is a speculation that the potency of autologous stem cell treatment may vary due to cell isolation methods, heterogeneity of the patients reflected as age, disease type and state.
This isn't a speculation that the people will one day rise up and throw their phones in the bin.
Second, in Washington there is more variation in the amount of rotation and more faulting, which has led to a speculation that the Crescent terrane has broken up into eight or nine crustal blocks.
Therefore, it is not simply a speculation that the phages would often encounter a much more concentrated host population when inside the biofilm.
Similar(48)
Taken together, these results support a speculation that in the presence of a well-coordinated development of the peri-sylvian regions, especially the anterior insula, the longitudinal course of schizophrenia could turn out to be more favorable.
Remember, you are borrowing short to lend long, a speculation that sank the savings and loan industry not long ago.
The observations led to a speculation that miRNAs might directly target the pluripotent core factors.
At this point it is no more than an attractive speculation that is consistent with the laws of physics.
Over breakfast at a New Jersey diner, Katz fired his longtime associate, putting an end to the speculation that had tortured Casey for the past six days.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com