The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs.
Cancer cells can acquire resistance to a single drug, to a class of cytotoxic or novel targeted drugs or to a broad spectrum of structurally and functionally unrelated drugs.
An analysis of the sequence variation revealed that the active domains of PI genes carry the signatures of an evolutionary arms race between plants and their enemies [9], [62]; hence the ability to produce a wide spectrum of structurally and functionally divergent PIs is likely important for PIs' defensive function.
Multidrug resistance, whereby patients become refractory to a broad spectrum of structurally unrelated compounds, is often implicated in the failure of chemotherapy regimens and eventual tumor progression.
SEREX-defined antigens represent a broad spectrum of structurally and functionally diverse proteins – transcription factors, adhesion molecules, signalling molecules, metabolic enzymes and cDNA sequences of 1549 antigens have been deposited in the SEREX database.
It binds a wide spectrum of structurally and functionally different ligands (Birn, 2006; Gliemann, 1998; Herz and Strickland, 2001), including vitamins, carrier proteins, lipoproteins, enzymes, hormones, and others (reviewed in (Birn, 2006; Willnow and Nykjaer, 2010)).
However, sunitinib has an even broader spectrum of structurally related receptors including VEGFR1 VEGFR3, and fms-related tyrosine kinase 3 (FLT3) and colony-stimulating factor-1 receptor (CSF-1R) [20], [21], [21].
Not only does the heart remodel structurally with prolonged intensive exercise, but athletes also demonstrate a spectrum of electrical alterations in the 12-lead ECG.
The wines displayed a spectrum of styles.
But there is a spectrum of rejectionists.
