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The folate receptor (FR) has been identified as a new molecularly targeted entity, which is highly overexpressed on the surface of a spectrum of solid tumor cells, including ovarian, kidney, lung, brain, endometrial, colorectal, pancreatic, gastric, prostate, testicular, bladder, head and neck, breast, and non-small cell lung cancer.
FRα exhibits limited normal tissue distribution, with measurable expression restricted to the apical surfaces of a few epithelia, predominantly in the lung, kidney, and choroid plexus, but is overexpressed in a spectrum of solid tumors, including ovarian cancer, non small cell lung cancer, breast cancer, kidney cancer and in high-grade osteosarcoma [7] [10].
Antifolates are antineoplastic agents, which are extensively used to treat a spectrum of solid tumors and hematologic malignancies.
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Cisplatin is a first-line therapy against a wide spectrum of solid neoplasms.
Cisplatin is one of the most effective anticancer drugs and is used as a first-line treatment for a wide spectrum of solid tumors, such as ovarian, lung and testicular cancer, and it is used for adjuvant therapy in gliomas.
Gemcitabine is a nucleoside analogue with activity against a broad spectrum of solid tumours, such as pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovary cancer (Hertel et al, 1990).
Cisplatin (cis-diamminedichloroplatinum II) has become a major chemotherapeutic agent for treatment of a wide spectrum of solid tumours.
6-Methoxy-3-(3′,4′,5′-trimethoxybenzoyl)-1H-indole 6-Methoxy-3- 3′,4′,5′-trimethoxybenzoyl -1H-indolelymerization which exhibits both in vitro and in vivo activities against a broad spectrum of solid tumors.
A contribution of HIF-1α to chemoresistance of neoplastic cells has been observed in a wide spectrum of solid tumors, including gastric cancer [6] [8], [17] [20].
The mTOR inhibitors have demonstrated clinical activities in a broad spectrum of solid tumours.
Mimics of let-7 and miR-34 are under preclinical development to target a broad spectrum of solid tumors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com