Since a consistent grammar distributes a unit probability over a spectrum of possible sequences, maximization of probabilities of the positive sample is always coupled with minimization of probabilities of the negative sample.
More precisely, the computational time for running a spectrum of a sequence containing N sites scales as JN ~ N2 (see Eq. 3).
GATA2 bound to a wider spectrum of sequences in vivo than anticipated, binding to a range of GATA repeats and palindromes previously hinted at by some in vitro studies (Badis et al., 2009; Trainor et al., 2000), and challenging the current view of uniformity of GATA factor DNA sequence recognition.
Multicellular eukaryotes also show a wide spectrum of sequences responsible for centromere specification.
Following the standards set by the original GAGE assembly comparison (Salzberg et al., 2012), GAGE-B (Genome Assembly Gold-standard Evaluation for Bacteria) evaluates how genome assemblers compare on a spectrum of bacterial genomes sequenced by the newest sequencing technologies.
Our results identified a spectrum of single base sequence alterations in 16 of the 21 genes selected for targeted re-sequence analysis.
We determined the score thresholds for a spectrum of six different sequence lengths (32,64,128,256,512,1024 aa) to take into account the increasing FPR for successively longer sequences.
There is a growing consensus that the genetic component of complex traits may reflect a different spectrum of sequence variants than the missense and nonsense mutations that dominate monogenetic diseases and traits.
In our case, the broader spectrum of sites that MBD2 recognizes provided the advantage of a broader spectrum of sequence information.
From a large collection of human PCR samples we selected 343 PCR products belonging to 16 disease genes and including a large spectrum of sequence variations previously identified by Sanger sequencing.
A full spectrum of sequence divergences between haplotypes was encountered, ranging from homozygous regions, via well-aligned heterozygous regions, to interruptions by inserts well in excess of 100 kb, and regions where sequence collinearity between haplotypes disappeared.
