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Collectively, these results underscore the need for careful evaluation of ZnO nanoparticle effects across a spectrum of relevant cell types when considering their use for potential new nanotechnology-based biological applications.
The variable responses of immune cells described in this study underscore the need for careful in vitro evaluation across a spectrum of relevant cell types, followed by appropriate in vivo studies to provide useful and potentially predictive screening data regarding the relative toxicity effects of metal-oxide NPs.
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The model is an interlocking set of differential algebraic equations developed from a broad spectrum of relevant measured and experiential data [ 16].
The upregulation of an array of the TFs suggests that the transgenic plants possess a robust system of transcriptional modulation towards the disease tolerance by regulating a large spectrum of relevant target genes of different TFs.
The combination of these agents has a broad spectrum of relevant activity.
Each spacecraft will carry hundreds of kilograms of propellant to enable deep dipping campaigns and to have the maneuverability to investigate a broad spectrum of relevant electrodynamic coupling scale sizes.
Because of the accurate, unambiguous identification of a wide spectrum of relevant mutations, the uncomplicated interpretation of the results, and the high-throughput nature, reliability and reproducibility, this method can easily be implemented in any clinical laboratory that is familiar with PCR.
By the turn of the century, American farmers and ranchers will be producing food and fiber through the application of highly sophisticated systems that involve a broad spectrum of relevant factors--from soil type, to options for fertilizer and pesticide use, to markets and other economic information.
Development of these systems has been the result of a collaborative effort of experts in bench and translational and clinical research from six continents aided by a spectrum of representatives from relevant medical societies, journals, and regulatory bodies.
Thus, the compound inhibits a spectrum of signal induction pathways relevant to inflammation and fibrosis, including PDGF signaling in synoviocytes, mast cell c-kit signaling, and TNF production by synovial fluid mononuclear cells.
There is a growing body of research investigating adolescent risk behaviors in China, however, a comprehensive measure that evaluates the full spectrum of relevant risk behaviors is lacking.
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CEO of Professional Science Editing for Scientists @ prosciediting.com