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Flavonoids are a class of compounds with polyphenolic structures and in all likelihood a spectrum of physiological functions can be expected depending on the position of hydroxyls and side chains.
Computational tools that can more rapidly generate tissue models that can represent a spectrum of physiological conditions will be highly useful for investigating metabolic dysfunctions in various diseases.
DNA methylation not only plays a crucial role in a spectrum of physiological processes, such as gene imprinting and X-chromosome inactivation [ 1], but is also associated with diseases including cancer, autoimmune maladies and psychiatric disorders [ 2].
Our data support the A. thaliana report in which the regulatory role of AtMYC2 on a spectrum of physiological processes was shown: from herbivore/pathogen defense to hormone biosynthesis; from primary and/or secondary metabolism [ 11, 70] to photomorphogenic development [ 32, 71].
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Considerable preclinical data show that oestrogen may be an effective intervention for a spectrum of severe physiological insults - for example, multiple trauma, head and spinal cord injury, burns, and sepsis (for example, [ 25, 26]).
Cyclic GMP is an important signaling molecule controlling a large spectrum of physiological responses in eukaryotes.
Circulating miRNAs become more widely studied and more used as a biomarker for the diagnosis of a broad spectrum of physiological, metabolic, and biochemical dysfunctions.
The interleukin-1β (IL-1β) is an important pro-inflammatory cytokine in a broad spectrum of physiological processes.
TNF receptor plays an important role in regulation of a wide spectrum of physiological process including the immune response.
DOI: http://dx.doi.org/10.7554/eLife.04346.005 We applied GEMOT to a large dataset of 1738 traits spanning a broad spectrum of physiological, biochemical, clinical, and behavioral traits that were measured across the genotyped BXD mouse recombinant inbred strains (a cross between the C57BL/6J and DBA/2J strains [ Wang et al., 2003]).
Whereas these findings were observed in the context of epileptogenesis, a neuroplasticity that leads to disease, they may apply to a broad spectrum of physiological and pathological activity-dependent plasticities in the mature hippocampus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com