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Monocytes can differentiate into a spectrum of functional macrophage phenotypes depending upon the microenvironment - such as presence of specific growth and differentiation factors- as well as on the receptors they express, signaling pathways and transcription factors [8],[8]].
The 1-year follow-up findings among this cohort of persons with WNV-associated paralysis demonstrate a spectrum of functional and strength outcomes.
This heterogeneity results in a spectrum of functional capabilities of FL-L1s, ranging from the inability to translate the encoded proteins to highly active forms in terms of retrotransposition [ 8].
We operationally define stem cells as a population with the unique ability to be maintained by a self-renewal program, yet equally capable of differentiating into a spectrum of functional cellular lineages.
The FIMM has well established reliability and validity and has been shown to have a high sensitivity for detecting functional improvement in patients across a spectrum of functional abilities and comorbidities [ 32, 39, 40].
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Older adults attending primary care clinics have multiple chronic conditions that result in a spectrum of cognitive, functional, and psychological symptoms.
The international literature has established an evidence base for the symptoms of dementia across a spectrum of cognitive, functional, behavioural, psychiatric, and physical domains that interrupt daily life of a person with dementia [ 23].
Dementia is a complex brain syndrome with a spectrum of cognitive, functional, behavioral, and psychological symptoms that reduces quality of life for both patients and their informal caregivers. 1, 2 Behavioral and psychological symptoms related to dementia are among the most difficult symptoms of the syndrome to manage.
The method permits the examination of a full spectrum of functional forms, as well as a determination of whether at all, to what degree, or within what range, the available time series data can be validly represented in a particular functional flux format within a pathway model.
Some lubricants, such as petroleum derivatives, are available in a great range of viscosities and thus can satisfy a broad spectrum of functional requirements.
It has been shown that Sac1 is essential for the development of multicellular organisms, and the deletion of Sac1 in yeast results in a broad spectrum of functional defects, including impaired membrane trafficking, an abnormal actin cytoskeleton, and altered lipid metabolism.
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