Only in our a priori specified subgroup of non-ventilated children was a modest and temporary reduction in days with wheeze found.
We address a highly controversially discussed issue - whether or not HES might be safe in specified subgroups of patients if correct indication is considered?
Notwithstanding the differences in the response to the intervention for some outcomes by sex and diabetes status, these weren't strong or consistent enough to suggest that the intervention should be limited to specified subgroups of patients.
24 We used a priori specified subgroup analyses, carried out independently of the significance of Q, to explore sources of heterogeneity: study quality, study design (cohort or case-control), preterm birth, if congenital malformations or meconium aspiration were controlled for or excluded, maternal obesity, and whether the effect of caesarean section as a mode of delivery was assessed.
Although analysts can use interaction terms to investigate hypotheses within the specified subgroup, analysts may wish to examine a subgroup of the sample excluding other sample members entirely.
b P value refers to the comparison of HV between survivors and nonsurvivors within the specified subgroup.
However, a high proportion of tumours from group 4 (approximately 40%) exhibited the molecular signature that specified subgroup 3. Consequently, we decided to bring together subgroups 3 and 4 for the rest of the study.
A comparison of the regression equations within the specified subgroups is shown in Table 3.
For comparative purpose of the test type and to distinguish between same or different fish species evaluation, a separate analysis was performed with specified subgroups.
One (4%) specified subgroups in advance [ 6], six (25%) adjusted for baseline differences as one of the reported analyses.
