R i is the rank of the ith gene of the specified pathway in a list, r i is the absolute correlation value r.
The genes in the specified pathway are graphically represented as a color-coded diagram.
The model proposed by Wallander and Varni allows the identification of modifiable risk and protective factors in patients' adjustment by testing specified pathways (1) with a clear description of the role of disease-related and psychosocial factors.
No relationship between the specified pathways simplifies the correction for multiple hypothesis testing.
Pathways listed are identified enriched pathways for indicated phenotypes; numbers in square brackets indicate the Kyoto Encyclopedia of Genes and Genomes (KEGG) identifiers for specified pathways.
The complexity of the response required a system-wide approach to data analysis, so the MetaCore™ software (GeneGo, Inc., St. Joseph, MI, USA) was used to assess the significance of changes in expression of genes in specified pathways [ 70, 71].
Traditional forms of microarray analysis result in long lists of significant differentially expressed genes or arbitrarily specified pathways and do not consider differential co-expression dynamics; rather they only focus on mean expression levels.
To validate the correctness of the inferred pathways we compute the recall and precision rates with respect to a specified reference pathway.
Few behavioural interventions specify a hypothesised mechanism of action of behaviour change techniques, and only a minority measure behaviour and its hypothesised determinants along a specified causal pathway.
