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Each subtype's catalytic pocket has a specificity for a particular substrate [ 7].
For instance, if an alpha-beta hydrolase exists with a specificity for a particular hydrolytic reaction, it will only take a small modification of a TIM-barrel with a related hydrolytic activity to evolve a pair of NISE.
In order to improve the therapeutic benefit and to confer to liposome a specificity for a certain cell or organ macromolecules such as antibodies, peptides and ligands of natural receptors are conjugated on liposome [ 17, 18].
This is because for a particular SLiM functional class the ELM resource's annotation process aims to curate the full spectrum of variation within eukaryotes; potentially this can allow too broad a specificity for a SLiM and lead to false positive results.
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Molecular modeling and docking and site-directed mutagenesis were carried out to engineer a PGT-3 having a specificity for isorhamnetin but not for quercetin.
At a level > 200 ng/ml, CD5L had a specificity for cirrhosis of 96% and a specificity for cancer of 60%.
Ginsberg et al determined that the rapid whole blood assay for D dimer has a sensitivity and a specificity for PE, as diagnosed by ventilation perfusion scan, of 85 and 68%, respectively [ 23].
Currently, it is not known if some EMT markers have a higher specificity for a specific renal disease, as studies comparing the expression of EMT markers between various human pathologies are few.
Taken together, TTF-1 had a better sensitivity, and Napsin A had a better specificity for the primary lung ADCs.
It has to be noted that F-FDG uptake is not a specific event, meaning that no specificity for a disease or target exists.
Another important aspect is given by the specificity for a particular tissue or for a specific pathology/injury.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com