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The differential transport properties of Box-GFP-Ub and Box-GFP-UbΔGG furthermore demonstrate that ubiquitin acts as a specific sorting signal, rather than merely triggering a degradation response due to the individual properties of the reporter.
This dual localization of membrane proteins at the PM and the tonoplast is not restricted to mutants which have lost a specific sorting signal, since it can also be observed when fluorescent PM proteins like the plasma membrane ATPase (PMA) or the LOW-TEMPERATURE-INDUCIBLE PROTEIN (LTI6a) are analyzed [ 24].
(534) Some of these processes might reflect a specific sorting process, as has been proposed to occur in a subapical compartment or common endosome, 535) or might be a manifestation of the biophysical properties of Cer, or perhaps an indicator of the broader process such as raft formation, with Cer serving as just one of many participants.
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ReprintsThe pattern in question is that many of the genes whose breakage leads to cancer are themselves involved in a specific sort of genetic regulation, known as epigenetics.
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