The phrase "a specific localisation in" is correct and usable in written English.
It can be used when referring to a particular location or position within a broader context, such as in geography, biology, or technology.
Example: "The study focuses on a specific localisation in the brain that is responsible for memory retention."
Alternatives: "a particular location in" or "a distinct site in".
However, in accordance with other groups (Labrecque et al, 1995; Luqmani and Shousha, 1995; Bonnet et al, 1999; Chu et al, 2001; Huang et al, 2003; Preciado et al, 2005; Arbach et al, 2006; Perkins et al, 2006; Tsai et al, 2007), we have shown the presence of EBV genetic information in a subset of BC tissue with a specific localisation in the epithelial malignant cells (Fina et al, 2001).
In Barrett's carcinoma (figure 6Di and ii) LGR5 mRNA shows a specific localisation at the bases of the malignant glands (n=5).
Studies with a conjugate of carboxypeptidase G2 (CPG2) and the F ab' 2 fragment of monoclonal anti-CEA antibody, A5B7, have shown specific localisation in a human colon tumour xenograft, LS174T, growing in nude mice.
In hippocampal and cortical neurons, the dominant effect that Kv2 channels exert on conduction is assisted by their specific localisation in the axon initial segment, where they act as a bottleneck low-pass filter to control AP output (Hwang et al., 1993; Sarmiere et al., 2008).
In HNX-HN bearing mice, E48 IgG as well as F ab' 2 showed highly specific localisation in tumour tissue.
The difference in expression in different cell lines and the specific localisation in CRC tissue, prompted us to test whether miR-200a expression might serve as a prognostic biomarker for CRC patients.
Furthermore, compartmentalisation of the proteins involved in the HIF response was rarely considered in most models, even though PHDs were shown to have specific localisation in the cell which could affect their activities [ 54].
Moreover, the identification of specific localisation patterns in fertile males, and their precise functional roles, would provide a key benchmark to which infertile sperm may be compared.
It is worth mentioning that AMPK has also been reported to have a differential and tissue-specific localisation pattern in mammalian cells, with the AMPKα1 subunit being mainly localised in the cytosol, and the AMPKα2 and β2 subunits being localised to the nucleus and cytosolic fractions [ 39– 42].
This hypothesis is sustained by the specific localisation of c-Yes in cholesterol-enriched microdomains found at adherent and tight junctions, probably due to an additional palmitoylation site present in c-Yes.
