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Here we describe a strategy which enables the identification of antibodies that bind unknown receptors with a specific expression profile.
This strategy allows the identification of epitopes with a specific expression profile (e.g., tumor-specific), independently of any biological information.
A novel and efficient tagArray technology was developed that allows rapid identification of antibodies which bind to receptors with a specific expression profile, in the absence of biological information.
This confirms Otx as the main driver for module A. Reverse mapping is applied on a specific expression profile in which the differentiation level (112) is achieved before 21 pfh, for the estimation of a series of input condition that establish such an expression profile.
Transcripts were selected as representatives of a cluster showing a specific expression profile.
These morphological changes result from a specific expression profile of surface markers, transcription factors and microRNAs (miRNAs).
It was not possible to define a specific expression profile discriminating positive from negative cases (Schnittger et al, 2002b).
Gene expression analysis is a common way to characterize gene expression profiles and to identify a specific expression profile(s) associated with a disease or trait.
No enrichment of other enzyme activity was detected in pollen-specific or stamen-specific datasets found previously [ 33], suggesting a specific expression profile of early anther development.
Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density.
One way to identify the conditions upon which a cis-sequence may confer gene expression is to analyse if genes harbouring this sequence in their promoter show a specific expression profile under certain environmental conditions (7).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com