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When hUCB MSCs are induced toward a specific differentiation pathway, the hUCB MSCs differentiate into the induced lineages specifically.
At 24 h after the transfection, the cells were induced to differentiate by exposure to RA for 3 days using a specific differentiation protocol (see above).
Fourthly, it is notable that implantation of TEC without any pretreatment to promote a specific differentiation pathway resulted in tissue repair associated with an active chondrogenic differentiation response.
Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type.
GFRa2+ spheroids are able to differentiate to secretory pituitary cells but also towards neuron-like phenotypes when driven appropriately with a specific differentiation medium.
Yet, the question of whether genetically unmodified intact cells that are already committed to a specific differentiation default can be reprogrammed to a different fate by ectopic microenvironmental cues, is still a matter of controversy [e.g. 2] [4].
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If IRE-1-mediated splicing of XBP-1 is triggered by a specific differentiation-dependent event rather than by the accumulation of misfolded aggregates, then XBP-1 activation itself may be an attractive target for drug therapy.
Alternatively, the differentiated cell sample may have reached a lineage specific differentiation stage where many of the genes expressed are specific to the developmental process (early organogenesis) and not relevant to the initiation of differentiation.
As a result, the reference fingerprints are small and all poses in which a molecule undergoes similar interactions get relatively high scores, so that a highly specific differentiation between actives and decoys directly at the beginning of the ranking is hardly possible.
In most other studies, there is neither a gender specific differentiation nor one between colon and rectal cancer [ 27, 38].
The rationale of the EB model was that early developmental processes simulated by EB differentiation would be affected by treatment of undifferentiated PSCs with toxic substances and, as a consequence, specific differentiation processes would be inhibited, induced or accelerated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com