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This was further confirmed in a mouse osteotomy model where a specific depletion of CD8+ T cells led to an improved bone healing [13].
Thus, a specific depletion of PMN might increase the susceptibility to S. pneumoniae-infection.
Thus, our analyses show that the proliferation of Spiroplasma in flies is associated with a specific depletion of hemolymph DAG as well as a decrease in the amount of fat body lipid storage.
As there is a specific depletion of Blimp1+ cells in SG of p53 TSD /− mice and the differentiation inducer PPAR γ is increased, our results suggest the depletion of the progenitor pool through enhanced differentiation.
Yet, our measurements do not allow discrimination between mitochondrial and cytosolic α-KG levels, and a role for a specific depletion of the cytosolic pool of α-KG in tumor biology cannot be excluded.
Moreover, it became apparent from the first full clinical description of AIDS in 1981 [ 3] that the salient feature underlying the disease is a specific depletion of CD4 T-helper lymphocytes.
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First, a clear induction of the apoptotic response has been observed in shPttg2-treated HEK293T cells showing a more specific depletion of Pttg2 than HCT116 cells treated in the same way.
Successful gene silencing by RNA interference requires a potent and specific depletion of the target mRNA.
In summary, we obtained a complete and specific depletion of nucleolar RPS9 using siRNA.
Second, our functional characterization of a 1.3 kb centromeric lncRNA deriving from centromeric transcription reveals its interaction with CENP-A and HJURP at eG1. Specific depletion of centromeric α-satellite transcripts affects the recruitment of both CENP-A and HJURP proteins, directly implicating centromeric RNA in CENP-A and HJURP targeting onto centromeres at eG1.
We find that PDD is a rapid procedure that results in effective and specific depletion of unwanted sequences from deep-sequencing libraries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com