The phrase "a specific accumulation of" is correct and usable in written English.
It can be used when describing a particular collection or gathering of items, data, or information that is distinct or defined in some way.
Example: "The research revealed a specific accumulation of evidence that supported the hypothesis."
Alternatives: "a particular collection of" or "a distinct gathering of".
A specific accumulation of mutations in transcribed regions was also observed with a different approach, i.e., mapping somatic mutations to the transcriptome of SCs obtained from the CAGE (cap analysis gene expression) RNA seq data of the FANTOM project28.
Biochemical analyses revealed a specific accumulation of neurexin-CTFs coinciding with reduced PS1 levels in cortical synaptosomes of PS cDKO mice.
Further evidence for a specific accumulation of the CaIX-P1 peptide was found in competition experiments revealing that the uptake of the radiolabeled ligand in CAIX positive SKRC 52 cells was reduced with increasing concentration of the unlabeled peptide, whereas octreotide as unspecific competitor at the same concentration had no effect.
This resulted in a specific accumulation of the antibody in the brain tumor but not in the normal brain, apparently leading to enhanced anti-tumor effect of Herceptin and increased survival of treated mice with HER2-positive lung and breast cancers implanted into the brain as a model of metastasis.
Particularly, Sucrenya cultivar showed a specific accumulation of obacunone and limonoate A-ring lactone.
Interestingly, an intense enlarged spot was observed on the simple Y arc, indicating a specific accumulation of replication intermediates.
Beyond to this two biological explanations, it is possible to say that a combination of several factors such a lifestyles, social networks, economic status, emotional life are frequently behind of an specific accumulation of deficits [ 39] Women showed a weaker association between the frailty index and the risk of dying over the next two years, as has also been found elsewhere [ 15, 22, 27].
For example using synchrotron radiation induced confocal micro X-ray fluorescence analysis (SR μ-XRF) we found a highly specific accumulation of Pb and Zn in the transition zone between mineralized and nonmineralized articular cartilage compared to subchondral bone [11,12].
In parallel, LPV treatment induced PARP-1 cleavage in a dose-dependent manner, as measured by the specific accumulation of an 89 kDa fragment in cells.
One possible strategy is to complex SOST with a bone-targeting moiety, such as a bisphosphonate, to allow the specific accumulation of SOST in the bone.
For an elevated and organ specific accumulation of their cargo, nanocarriers need to avoid opsonization, activation of the complement system and uptake by macrophages of the mononuclear phagocyte system.
