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The phrase "a source of anguish" is correct and usable in written English.
It can be used to describe something that causes significant emotional pain or distress.
Example: "The loss of her beloved pet became a source of anguish that she struggled to overcome."
Alternatives: "a cause of suffering" or "a source of distress."
Exact(13)
For the Smiths, the bulldozing of city blocks is a source of anguish.
The apparent indifference to his suffering was in itself a source of anguish.
"You have no idea what a source of anguish my wife's illness has been to me".
"Germany's undisputed economic dominance and its policy assertiveness are a source of anguish".
Even if default is averted, the nation's mountainous debt will likely remain a source of anguish and acrimony through and even past the 2012 election.
That may not mean much to a lot of people, but it will matter a great deal to the Conways, a source of anguish for ever.
Similar(47)
Everything begins with the text and this is a source of great anguish to me.
To Sandy, it was a source of some anguish that their children still did not know the truth about him.
For now, it's the mystery of the year — and a source of immense anguish for the families of the missing passengers and crew.
Mr. Jabari was involved in the negotiations to release Mr. Shalit, whose five years as a prisoner was a source of national anguish.
Military officials had not yet contacted her, she said, and that has been a source of continued anguish during the two months since.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com