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Thus, they can provide a sound initial platform for protein-based design of new molecules capable of targeting the E-box and modulating the Myc transcription factor network.
I applaud the work of Charyeva and colleagues as a sound initial "proof of concept," but we must have more robust discussion on how to fully implement task sharing across contexts from all who share similar results.
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Some of the UK's oldest and most successful brands are testament to sound initial choices, brand consistency and carefully chosen strategic development – all underpinned by the crucial protection that trademarks offer.
For people who plan to move in a few years and for those who expect their income to rise, an adjustable rate mortgage can be a sound alternative, because the initial interest rate is less than for a fixed-rate loan.
The revised model of athletic injury aetiology (Meeuwisse et al. 2007), for example, represents a sound attempt at advancing the initial static and linear paradigm, but systemic and interpersonal determinants are not featured.
The team also observed that if the finch heard a sound fewer times during the initial learning period, or if the repetitions were close together, the memory disappeared more quickly.
One may ask why TMS produced a clear and significant effect on tongue-sound-initial words but not on lip-sound-initial word processing.
The ANOVA on reaction times revealed a significant main effect for Word Type (lip-word-initial, "lip word" vs. tongue-sound-initial, "tongue word") (F1,12 = 9.6, P = 0.009) and a significant interaction between Word Type and TMS Location (F1,12 = 7.1, P = 0.021).
This observation might explain why functional TMS interference was easier for tongue- than for lip-sound-initial words.
This indicates that, in spite of all measures taken to control between stimulus materials, tongue-sound-initial items were already more difficult to process, thus being more sensitive to minimal TMS-elicited interference.
In essence, several reasons may explain why causal effects of motor cortex stimulation were pronounced for tongue-sound-initial words, but marginal for lip words considered separately; importantly, however, the significant interaction of stimulation site and phonemic word type proves that motor cortex stimulation altered word comprehension processes in a phoneme-specific manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com