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The main limitations are lack of a pure control group and a somewhat small sample size.
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It was taken in a shorter time, with a somewhat smaller sample (and a higher margin of sampling error) than most Times/CBS News surveys.
The analysis of a somewhat smaller sample with complete data and no imputation confirmed our results, which indicated that missing data were random.
We judged that a somewhat smaller sample size would be sufficient for our purpose because we expected the regression analysis to have greater statistical power to detect a treatment effect than a usual t-test [ 42].
To avoid the possibility of a false positive association of CTLA-4 +49A/G*A with pSS as a result of the somewhat small sample size of our first cohort, and because the CTLA-4 +49alleleallele has been only marginally associated with autoimmune diseases compared with the CTLA-4 +49alleleallele [ 1], we performed a replication study on a second independent cohort of 139 patients with pSS.
Due to the somewhat small sample size and considerable stability of life satisfaction in the long-term perspective, the changes in life satisfaction over time were investigated to a limited extent with respect to the identified correlates.
In our study, loss of patients due to revision, death, and ill health was underestimated, resulting in somewhat small samples.
TC: This is a fairly small sample size.
Moreover, the maximum likelihood estimation procedure, used in this study, requires somewhat smaller sample sizes (Kline 2005).
For comparison, we conducted a post-hoc analysis also examining the accuracy of the full 33-item MFQ among the somewhat smaller sample of children who were administered the full MFQ.
Second, in somewhat smaller samples, relatively simple methods, able to deal with one or two of above data characteristics, may be preferable but checking sensitivity to assumptions is necessary.
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CEO of Professional Science Editing for Scientists @ prosciediting.com