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To a solution of compound 4 (1.10 g, 6.75 mmol) in ethanol (12 mL), Conc.
The single crystal was obtained by slow evaporation of a solution of compound 10g in ethyl acetate at room temperature.
A solution of compound 3 (50 mmol) in THF (100 mL) was then added to the reaction mixture at this temperature.
To a solution of compound 3 (2 g, 13.60 mmol) in DMF (15 vol), Oxone was added (40.80 mmol) at 5°C and stirred for 2 h.
A solution of compound 4 (220 mg, 0.354 μmol) in 3 mL of MeOH was stirred with 10 mg of Pd/C under H2 atmosphere for 12 h.
Sodium hydride (70 mg, 3.0 mmol) was added to a solution of compound 6 (or 10) (2.5 mmol) in dry THF (70 mL), and the resulting mixture was stirred under N2 at ambient temperature for 1 h.
Similar(18)
This returns to an older pharmacological modality, in which a "model system" might be a guinea pig ileum perfused in an solution of compound (57), except that now tens of thousands of compounds are screened.
A solution of compounds 22a b (0.01 mol) in acetic anhydride (10 mL) was heated for 15 min.
A solution of compounds in a mixture of acetic anhydride pyridine (1 1) were stirred fully and settled at 25 °C for 12 h.
To a solution of compounds 4a 4f (2 mmol) in 50 mL of dry benzene was added 0.312 g (2 mmol) of 3,4-dithio-toluene and 0.2 mL of triethylamine.
A solution of compounds 1e – 3e, 5e – 14e, 16e 18ee–18e (10 mmol) in MeOH (50 mL) presaturated with hydrogen chloride was heated under reflux for 2 h.
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