Recently, based on the "barrel-stave" model and the "carpet" model, Chen et al. proposed a "membrane discrimination" model for AMPs whose sole target is the biomembrane, and the peptide specificity to eukaryotic or prokaryotic cells depends upon the compositional difference in the lipids of membranes (Chen et al., 2005; Chen et al., 2007).
Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis.
HBX 41,108 specificity is limited because it inhibits USP5, USP8, UCH-L3 and caspase 3 in addition to USP7, a DUB that was initially identified as the sole target of HBX 41,108 [ 54].
To identify if FtsH is the sole target responsible for CIII growth inhibition we constructed a plasmid carrying the pBAD-CIII-GFP fusion.
In S. cerevisiae, we know that monopolin is a key target of Spo13/Cdc5, though whether monopolin is the kinase's sole target with regard to co-orientation is unclear.
I now realize that it was not the boycott per se that caused me rage, but the tolerance for a double standard that said "While others -- including our own United States -- commit war crimes, engage in oppression, and have a long history of subjugating, disenfranchising and dehumanizing minorities, Israel will be our sole target".
If ALS is the sole target, can the decrease of BACC levels cause so evident a retardation of growth?
However, it is clear from Figure 2 that there is not an obvious relationship linking any of the kinases identified as being the sole target responsible for the biological activity of YA1.
