A neuroprotective role with a sole function as a cytoplasmic Ca2+ buffer has been postulated for CaBPs, the impairment of which leads to the failure of buffering of the intracellular Ca2+ and neuronal death [ 28].
For normal aging, age-related brain atrophy is a mild process, responsible for increased risk of memory decline with increasing age (Pakkenberg et al., 2003; Fox and Schott, 2004), whereas the highly accelerated rate of brain atrophy has a major or sole role in neurodegenerative diseases (Regeur et al., 1994; Schott et al., 2003).
CVP rarely exists in isolation in later life, and CVP most likely plays a supporting role, rather than a sole leading role, in the pathogenesis of dementia.
The Fund should have insisted on a currency board, a legally constituted independent body whose sole role is to maintain a predetermined exchange rate.
And Mr. Fellas, who was inside, said that he was not Evdin's general director, but "a nominee director" whose sole role was to register the company.
Every now and then, a tiny person dressed as a French maid pops up, her sole role apparently to sweep the floors – a truly sisyphean task.
The aim of this study was to map and analyse the workflow functions of an existing care coordination workforce whose sole role was within a care coordination service.
These signalling intracellular pathways play a crucial but not the sole role in macrophage reprogramming.
On the other hand, males' sole role of a breadwinner puts them at greater risk of heavy drinking, especially in times when this role cannot be adequately fulfilled (Ashwin and Lytkina, 2004; Kiblitskaya, 2000; Watson, 1995).
However, in view of the well-documented role of the S1 gene in reovirus pathogenesis, we favour the idea that the nonsense mutation in S1 likely has a major, if not the sole, role in AV virus attenuation.
