The number of individuals we used, as well as the consistent genotype frequency changes we observe in our replicate competition assays make genetic drift an unlikely sole cause of the changes we see.
A similarly large study by Ratnam et al. also looked specifically at the role of pelvic venous embolization in the management of lower limb varicosities [ 27]. 218 patients with pelvic venous incompetence as either a contributing factor or sole cause of varicose leg veins diagnosed exclusively with transvaginal duplex sonography were treated exclusively with platinum coil embolization.
Obesity itself is not an illness, nor the sole cause of metabolic syndrome, and not only are there different kinds of obesity (being big-waisted is more dangerous than being big-butted), plenty of people who have metabolic syndrome aren't obese at all.
She ran tests on families affected by the disorder and found that a mutation in a gene called SCA1 was the sole cause of the disease.
Now, this doesn't mean that climate change was the sole cause of a particular event.
"It is insulting to those who took their destiny into their own hands and took the decision to march together, to think that a flyer could be the sole cause of their decision-making," the group posted on it's Idomeni Live Ticker blog.
It seems unlikely that a stress response is the sole cause of elevated TE expression as other families are more highly expressed in the amoeboid adherent and aggregate stages.
Acute renal failure was invariably present at hospital admission, but could have hardly represented the sole cause of such a dramatic rise in blood lactate levels.
They further showed that the antiproliferative effect of the inhibitors was partially reversed after CDK inhibition (Roscovitine), suggesting that CDK hyperactivity may be a contributing factor, rather than the sole cause of the antiproliferative effect of Chk1 and Wee1 inhibition.
"I can't think of an accident where weather was the sole cause of the problem," she says.
